Thyroid Antibodies – 2 Types
It is important to remember that an HE diagnosis rests in significant part on the patient’s thyroid antibody levels. Patients may have elevated levels of either, or both, thyroid antibodies: Thyroid Peroxidase antibody (TPO), and/or Thyroglobulin antibody (TgAb).
Although TPO elevations are the numbers physicians usually focus on, in some cases the degree of elevation of a patient’s TgAb level may be more dramatic than that of the TPO level. (See “Antithyroid antibodies in the CSF: Their role in the pathogenesis of Hashimoto’s encephalopathy, ” at http://www.neurology.org/content/60/4/712.full?ijkey=62ca05218d3fae1c1898b7e4939691ba497d1c59 ; see also Schiess, N. and Pardo, C. A. (2008), Hashimoto’s Encephalopathy. Annals of the New York Academy of Sciences, 1142: 254–265. )